Inflammation and destruction of bile ducts in the liver, usually due to an autoimmune disease in which the body’s immune system mistakenly attacks healthy tissues.

Essentials of Diagnosis:-

• Symptoms of long standing cholestasis either due to carcinoma head of pancreas or choledo- cholithiasis.
• Serum is negative for mitochondrial antibodies.

Treatment:-

-Removal of causative factors are symptomatic treatment.

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