Zollinger–Ellison syndrome is a rare condition in which one or more tumors form in your pancreas or the upper part of your small intestine (duodenum). These tumors, called gastrinomas, secrete large amounts of the hormone gastrin, which causes your stomach to produce too much acid.
• Severe uncontrollable peptic ulcer syndrome.
• Gastric hypersecretion.
• Elevated serum gastrin more than 300 pg/ml.
• Gastrinoma of pancreas, duodenum or at other
-For prolonged period/Famotidine/Ranitidine/ Omeprazole / pantaprazole /Somprazole may be given in higher doses.
-Omeprazole /Pantaprazole 40-80 mg od.
-If unresponsive to drugs surgical resection is advised.